Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8292444 | Biochemical and Biophysical Research Communications | 2018 | 5 Pages |
Abstract
Interferon regulatory factor (IRF) 4 and the proto-oncogene c-Rel cooperate in growth and antiviral drug resistance of adult T-cell leukemia/lymphoma (ATLL). To elucidate the target of IRF4 and c-Rel in ATLL, we determined the simultaneous binding sites of IRF4 and c-Rel using ChIP-seq technology. Nine genes were identified within 2â¯kb of binding sites, including MIR3662. Expression of miR-3662 was regulated by IRF4, and to a lesser extent by c-Rel. Cell proliferation was inhibited by knockdown of miR-3662 and expression of miR-3662 was correlated with antiviral drug resistance in ATLL cell lines. Thus, miR-3662 represents a target for therapies against ATLL.
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Authors
Kiyoshi Yasui, Mai Izumida, Takeya Nakagawa, Yoshinao Kubo, Hideki Hayashi, Takashi Ito, Hiroaki Ikeda, Toshifumi Matsuyama,