| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8292463 | Biochemical and Biophysical Research Communications | 2018 | 8 Pages |
Abstract
Proposed mechanism of IDD-24 mediated improvement in insulin resistance in diabetic mice. A new anti-advanced glycation end products (AGEs) agent, IDD-24, decelerated AGEs formation in genetic mice model of diabetes. IDD-24 diminished RAGE - nuclear factor-κB signaling. Inhibition of JNK caused reduced serine phosphorylation of Insulin receptor substrate -1 (IRS-1) and hence enhanced insulin sensitivity.151
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Authors
Gulnaz Khan, Meha Fatima Aftab, Bilquees Bano, Khalid Mohammed Khan, Munazza Murtaza, Sonia Siddiqui, M.Hafizur Rehman, Rizwana Sanaullah Waraich,