Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8292555 | Biochemical and Biophysical Research Communications | 2018 | 7 Pages |
Abstract
The ZFP36 family is a prototypical member of a highly conserved group of proteins with CCCH-type RNA-binding domains, whose functional role and regulatory mechanism in mitotic cells remain obscure. In this study, we provide the first evidence that ZFP36L1 phosphorylation is modulated in a cell cycle-dependent manner. The C-terminal region of ZFP36L1 is critical for its cell cycle-dependent phosphorylation of this protein. We also suggest that the phosphorelay-dependent regulation of ZFP36L1 influences mitotic spindle organization. Thus, our data demonstrate a new class of regulatory mechanism for CCCH-type zinc-finger proteins in cell cycle control.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Makoto Kondo, Aya Noguchi, Yuki Matsuura, Masumi Shimada, Naoto Yokota, Hiroyuki Kawahara,