Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8292857 | Biochemical and Biophysical Research Communications | 2018 | 7 Pages |
Abstract
Atherosclerosis is a dyslipidemia disease characterized by foam cell formation driven by the accumulation of lipids. Visceral adipose tissue-derived serine protease inhibitor (vaspin) is known to suppress the development of atherosclerosis via its anti-inflammatory properties, but it is not yet known whether vaspin affects cholesterol efflux in THP-1 macrophage-derived foam cells. Here, we investigated the effects of vaspin on ABCA1 expression and cholesterol efflux, and further explored the underlying mechanism. We found that vaspin decreased miR-33a levels, which in turn increased ABCA1 expression and cholesteorl efflux. We also found that inhibition of NF-κB reduced miR-33a expression and vaspin suppressed LPS-mediated NF-κB phosphorylation. Our findings suggest that vaspin is not only a regular of inflammasion but also a promoter of cholesterol efflux.
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Authors
Jia-Hui Gao, Meng-Ya Zeng, Xiao-Hua Yu, Gao-Feng Zeng, Lin-Hao He, Xi-Long Zheng, Da-Wei Zhang, Xin-Ping Ouyang, Chao-Ke Tang,