Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8294302 | Biochemical and Biophysical Research Communications | 2018 | 8 Pages |
Abstract
ADP-ribosylation factor-like 4C (ARL4C) has been shown to play an important role in cholesterol secretion, microtubule dynamics, and cell morphological changes. However, its role in osteogenesis has not been explored. In this study, we found that ARL4C is downregulated during the osteogenic differentiation of human adipose derived stem cells (hASCs). Knockdown of ARL4C suppresses osteogenesis of hASCs in vitro and in vivo. We demonstrate that ARL4C knockdown likely attenuates osteogenesis of hASCs through inhibition of the Wnt signaling pathway. These results provide new insights into the mechanisms of osteogenic differentiation and provide a potential molecular target for bone tissue engineering.
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Authors
Wensi Wang, Siyi Wang, Xuenan Liu, Ranli Gu, Yuan Zhu, Ping Zhang, Yunsong Liu, Yongsheng Zhou,