Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8294460 | Biochemical and Biophysical Research Communications | 2018 | 7 Pages |
Abstract
Age-associated dysfunction of retinal pigment epithelial cells (RPEs) is considered to be the initial trigger of retinal diseases such as age-related macular degeneration. Although autophagy is upregulated in RPEs during the course of aging, little is known about how autophagy is regulated and its functional role in RPEs. In this study, we found that expression of Sirtuin 6 (SIRT6) and autophagic markers are upregulated in RPEs of aged mice where subretinal deposition of amyloid-β is accumulated and in amyloid-β stimulated RPEs. In addition, gain and loss-of-function studies confirmed the positive role of SIRT6 in regulating autophagy. Interesting, inhibition of autophagy attenuates amyloid-β stimulated inflammatory response in RPEs. Collectively, our findings uncover the autophagy modulated by SIRT6 may be a proinflammatory mechanism for amyloid-β induced RPE dysfunction.
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Authors
Yiji Feng, Jian Liang, Yuanqi Zhai, Junran Sun, Jing Wang, Xiangjun She, Qing Gu, Yang Liu, Hong Zhu, Xueting Luo, Xiaodong Sun,