| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8295251 | Biochemical and Biophysical Research Communications | 2018 | 7 Pages |
Abstract
The mitochondrial targeting domain (MTD) of Noxa has necrosis-inducing activity when conjugated with cell-penetrating peptide (CPP). In this study, we report another MTD-like motif, B1MLM, found in BNIP1, a pro-apoptotic BH3-only protein found in the endoplasmic reticulum membrane. The B1MLM peptide, conjugated with CPP, induced necrosis in a way similar to that of R8:MTD. R8:B1MLM caused an intracellular calcium spike, mitochondrial reactive oxygen species generation, and mitochondrial fragmentation. The cytosolic calcium spike was likely due to the opening of the mitochondrial permeability transition pore.
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Authors
Junghee Park, Ji-Hye Han, Seung-Hyun Myung, Young-Woo Seo, Tae-Hyoung Kim,