Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8295510 | Biochemical and Biophysical Research Communications | 2018 | 7 Pages |
Abstract
Allograft inflammatory factor-1 (AIF-1) is a protein expressed by macrophages infiltrating the area around the coronary arteries in a rat ectopic cardiac allograft model. We previously reported that AIF-1 is associated with the pathogenesis of rheumatoid arthritis and skin fibrosis in sclerodermatous graft-versus-host disease mice. Here, we used an animal model of bleomycin-induced lung fibrosis to analyze the expression of AIF-1 and examine its function in lung fibrosis. The results showed that AIF-1 was expressed on lung tissues, specifically macrophages, from mice with bleomycin-induced lung fibrosis. Recombinant AIF-1 increased the production of TGF-β which plays crucial roles in the mechanism of fibrosis by mouse macrophage cell line RAW264.7. Recombinant AIF-1 also increased both the proliferation and migration of lung fibroblasts compared with control group. These results suggest that AIF-1 plays an important role in the mechanism underlying lung fibrosis, and may provide an attractive new therapeutic target.
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Authors
Hidetake Nagahara, Takahiro Seno, Aihiro Yamamoto, Hiroshi Obayashi, Takuya Inoue, Takashi Kida, Amane Nakabayashi, Yuji Kukida, Kazuki Fujioka, Wataru Fujii, Ken Murakami, Masataka Kohno, Yutaka Kawahito,