| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8295693 | Biochemical and Biophysical Research Communications | 2018 | 28 Pages |
Abstract
Micro RNAs (miRNAs) are small non-coding RNAs which are 19-24 nucleotides in length. MiRNAs play a vital role in the whole process of tumour development, but how they influence the tumourigenecity of epithelial ovarian cancer (EOC)cells is rarely researched. In our study, it was verified that miR-628-5p decreased the stem like cell percentage of EOC cells by inducing their apoptosis. The animal experiments showed that miR-628-5p decreased the tumourigenecity of EOC cells. Besides, we found miR-628-5p targeted at and down-regulated the expression of fibroblast growth factor receptor 2 (FGFR2). FGFR2 expressed higher in ovarian cancer tissues and was correlated with worse prognosis. Our findings indicated that miR-628-5pplays an important role in ovarian cancer stem cell driven tumorigenesis.
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Authors
Ming Li, Zhimin Qian, Xiaoling Ma, Xiaolong Lin, Yanan You, Yiying Li, Tong Chen, Hua Jiang,