| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8295975 | Biochemical and Biophysical Research Communications | 2017 | 19 Pages |
Abstract
PGE2 is an inflammatory mediator and PGE2 can stimulate different G proteins, depending on the type of EP subtype engaged, inducing changes in second messengers such as cAMP, Ca2+, and inositol phosphates. After binding to ATR1, AngII increases intracellular level of PGE2 which, in turn, drives Clâ secretion by stimulating cAMP- dependent cystic fibrosis transmembrane conductance regulator (CFTR) in the apical membrane of intestinal epithelial cells. In addition, COX enzymes involves the AngII-evoked response in rat ileum. Taken together, AngII evokes a secretory response in rat ileum, which is mediated through PGE2 formation via ATR1 and cAMP- dependent Clâ secretion was involved in AngII-induced stimulatory effect.217
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Authors
Ling Xiao, Hong-Wei Liu, Hong Di, Li-Xin Chen, Qing Zhou, Xin Yu, Haiyan Jing, Shuhai Tang,