Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8297025 | Biochemical and Biophysical Research Communications | 2014 | 5 Pages |
Abstract
Two new MRI contrast agents, Gd-DOTA-c(RGD-ACP-K) (1) and Gd-DOTA-c(RGD-ACH-K) (2), which were designed by incorporating aminocyclopentane (ACP)- or aminocyclohexane (ACH)-carboxylic acid into Gd-DOTA (gadolinium-tetraazacyclo dodecanetetraacetic acid) and cyclic RGDK peptides, were synthesized and evaluated for tumor-targeting ability in vitro and in vivo. Binding affinity studies showed that both 1 and 2 exhibited higher affinity for integrin receptors than cyclic RGDyK peptides, which were used as a reference. These complexes showed high relaxivity and good stability in human serum and have the potential to improve target-specific signal enhancement in vivo MR images.
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Authors
Ji-Ae Park, Yong Jin Lee, In Ok Ko, Tae-Jeong Kim, Yongmin Chang, Sang Moo Lim, Kyeong Min Kim, Jung Young Kim,