Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8297295 | Biochemical and Biophysical Research Communications | 2014 | 7 Pages |
Abstract
In addition to their remarkable stimulatory effects on proinflammatory gene transcription, three of the most frequently prescribed antipsychotic drugs, clozapine, quetiapine and aripiprazole, also induced the expression of essential adipocyte differentiation genes and the adipocyte hormones leptin and adiponectin, suggesting that both glucose and fat metabolism may be affected by these drugs. These data further suggest that antipsychotic treatments in patients alter the gene expression patterns in adipocytes in a coordinated fashion and priming them for a low-level inflammatory state.
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Authors
Anitta K. Sárvári, Zoltán Veréb, Iván P. Uray, László Fésüs, Zoltán Balajthy,