Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8297320 | Biochemical and Biophysical Research Communications | 2013 | 6 Pages |
Abstract
Autophagy is a cellular degradation process for cellular aggregates and unneeded cellular compartments including damaged mitochondria, ER, and peroxisomes. Melanosome is cellular organelle that is the cellular site of generation, storage and transports of melanin in melanocytes. Despite potential importance of autophagy, the role of autophagy in melanogenesis and melanosome autophagy are largely unknown. In here, we identified 3â²-hydroxydaidzein (3â²-ODI) as an autophagy inducer from a phytochemical library screening. Treatment with 3â²-ODI significantly reduced α-MSH-mediated melanogenesis but efficiently increased autophagy both in melanoma cells and melanocytes. Furthermore, inhibition of autophagy significantly reduced the anti-melanogenic effects of 3â²-ODI in α-MSH-stimulated melanoma cells. Taken together, these results suggest that autophagy mediates anti-melanogenic activity of 3â²-ODI.
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Authors
Eun Sung Kim, Ji Hyun Shin, Su Hyeon Seok, Jun Bum Kim, Huikyoung Chang, So Jung Park, Yoon Kyung Jo, Eun Sun Choi, Jun-Seong Park, Myeong Hun Yeom, Chol Seung Lim, Dong-Hyung Cho,