| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8297444 | Biochemical and Biophysical Research Communications | 2014 | 6 Pages |
Abstract
Jun dimerization protein 2 (JDP2) is a repressor of transcription factor AP-1. To investigate the transcriptional regulation of the JDP2 gene, we cloned the 5â²-flanking region of the mouse JDP2 gene. Primer extension analysis revealed a new transcription start site (+1). Promoter analysis showed that the region from nt â343 to nt +177 contains basal transcriptional activity. Interestingly, the tumor suppressor p53 significantly repressed the transcriptional activity of the JDP2 promoter. Given that JDP2 inhibits expression of p53, our results suggest a negative feedback loop between JDP2 and p53, and a direct link between JDP2 and a key oncogenic pathway.
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Authors
Yuanhong Xu, Chunyuan Jin, Zhe Liu, Jianzhi Pan, Hongjie Li, Zhongbo Zhang, Shulong Bi, Kazunari K. Yokoyama,