Clinical significance of proliferation, apoptosis and senescence of nasopharyngeal cells by the simultaneously blocking EGF, IGF-1 receptors and Bcl-xl genes

Article ID	Journal	Published Year	Pages	File Type
8297639	Biochemical and Biophysical Research Communications	2013	6 Pages	PDF

Abstract

Simultaneously blocking EGFR, IGF1R and Bcl-xl genes is capable of altering the balance between proliferating versus apoptotic and senescent cells in the favor of both of apoptosis and senescence and, therefore, the tumor cells regression.

Keywords

Bcl-xL short hairpin RNA Nasopharyngeal cancer Senescence Insulin-like growth factor-1 receptor Epidermal growth factor receptor

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Clinical significance of proliferation, apoptosis and senescence of nasopharyngeal cells by the simultaneously blocking EGF, IGF-1 receptors and Bcl-xl genes

Authors

Guodong Dai, Tao Peng, Xuhong Zhou, Jun Zhu, Zhihua Kong, Li Ma, Zhi Xiong, Yulin Yuan,