| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8297780 | Biochemical and Biophysical Research Communications | 2013 | 6 Pages |
Abstract
⺠In obese mice, TACE activity increases only in visceral adipose tissue (VAT). ⺠Caloric restriction (CR) reduces TACE expression and activity in VAT of KK-Ay mice. ⺠CR reduces phosphorylation of JNK and p38MAPK, but not of ERK, in VAT of KK-Ay mice. ⺠CR reduces TNFα expression and shedding of pro-TNFα in VAT of KK-Ay mice. ⺠Exogenously administered TNFα activates TACE, JNK and p38MAPK in VAT of KK-Ay mice.
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Authors
Shuji Kawasaki, Hiroyuki Motoshima, Satoko Hanatani, Yuki Takaki, Motoyuki Igata, Atsuyuki Tsutsumi, Takeshi Matsumura, Tatsuya Kondo, Takafumi Senokuchi, Norio Ishii, Hiroyuki Kinoshita, Kazuki Fukuda, Junji Kawashima, Seiya Shimoda, Takeshi Nishikawa,