| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8297847 | Biochemical and Biophysical Research Communications | 2013 | 6 Pages |
Abstract
⺠Both C-and N-termini of hTLR9 ECD are necessary for receptor signaling activation. ⺠H505, H530, and Y554 form receptor-ligand recognition sites of hTLR9 ECD. ⺠CpG ODN-PD acts in sequence-dependent manner to stimulate hTLR9. ⺠CpG ODN-PTO resembles sequence-independent fashion of hTLR9 in PBMC and B cells.
Keywords
IL-6PTOcytosine–phosphate–guanineLRRPBMCsTLRoligodeoxynucleotideODNCpGIRSPAMPsECDNF-κBpathogen-associated molecular patternsImmunostimulatoryinterleukin-6Leucine rich repeatToll-like receptorextracellular domainperipheral blood mononuclear cellsNuclear factor-kappa BPhosphorothioatephosphodiesterToll-like receptor 9
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Authors
Suwarti Suwarti, Tomohiko Yamazaki, Chechetka Svetlana, Nobutaka Hanagata,