Structure of the complex of Neisseria gonorrhoeae N-acetyl-l-glutamate synthase with a bound bisubstrate analog

Article ID	Journal	Published Year	Pages	File Type
8297872	Biochemical and Biophysical Research Communications	2013	6 Pages	PDF

Abstract

âº Preparation of a bisubstrate analog CoA-NAG using enzyme itself as the catalyst. âº Determination of the structure of the complex of ngNAGS bound with CoA-NAG. âº Mutagenesis and kinetic studies of active site residues. âº Catalytic mechanism for ngNAGS enzymatic reaction.

Keywords

RMSD NAT NAG NAGS N-acetyl-l-glutamate N-acetyl-l-glutamate kinase Bisubstrate analog aAK NAGK N-acetyltransferase amino acid kinase Arginine biosynthesis GNAT

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Structure of the complex of Neisseria gonorrhoeae N-acetyl-l-glutamate synthase with a bound bisubstrate analog

Authors

Gengxiang Zhao, Norma M. Allewell, Mendel Tuchman, Dashuang Shi,