| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8297881 | Biochemical and Biophysical Research Communications | 2013 | 6 Pages |
Abstract
⺠We examined effect of the quaternary structure of yeast sHsp on Aβ aggregation. ⺠Aβ aggregation was inhibited by the oligomeric form of sHsp, but not by dimeric sHsp. ⺠The fibrillar amyloids consisted of both Aβ and dimeric sHsp. ⺠They exhibited different inner structure and cytotoxicity from authentic Aβ amyloids. ⺠These results suggest the formation of new type fibrillar Aβ amyloid by sHsp.
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Authors
Masafumi Sakono, Arata Utsumi, Tamotsu Zako, Tetsuya Abe, Masafumi Yohda, Mizuo Maeda,