| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8297884 | Biochemical and Biophysical Research Communications | 2013 | 7 Pages |
Abstract
⺠Mechanism of cell toxicity by acrolein was studied using mouse FM3A cells. ⺠GAPDH was one of the major acrolein-conjugated proteins in cells. ⺠Acrolein interacted with cysteine-150 at the active site of GAPDH. ⺠Cell death was enhanced by acrolein-conjugated GAPDH. ⺠Inactivation of GAPDH is one mechanism of cell toxicity by acrolein.
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Authors
Mizuho Nakamura, Hideyuki Tomitori, Takehiro Suzuki, Akihiko Sakamoto, Yusuke Terui, Ryotaro Saiki, Naoshi Dohmae, Kazuei Igarashi, Keiko Kashiwagi,