Ombuin-3-O-β-d-glucopyranoside from Gynostemma pentaphyllum is a dual agonistic ligand of peroxisome proliferator-activated receptors α and δ/β

► Ombuin-3-O-β-d-glucopyranoside is a dual ligand for PPARα and δ/β. ► Ombuin-3-O-β-d-glucopyranoside reduces cellular lipid levels in multiple cell types. ► Cells stimulated with ombuine up-regulated target genes in cholesterol efflux. ► Cells stimulated with ombuine regulated target fatty acid β-oxidation and synthesis. ► Ombuin-3-O-β-d-glucopyranoside could ameliorate hyperlipidemia and hepatic steatosis.