| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8297947 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠The phosphorylated or activated form of STAT3 was expressed in colon cancer stem-like cells. ⺠STAT3 inhibitor, FLLL32 inhibits P-STAT3 and STAT3 target genes in colon cancer stem-like cells. ⺠Inhibition of STAT3 resulted in decreased cell viability and reduced numbers of tumorspheres. ⺠STAT3 is required for survival and tumorsphere forming capacity in colon cancer stem-like cells. ⺠Targeting STAT3 in cancer stem-like cells may offer a novel treatment approach for colon cancer.
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Authors
Li Lin, James Fuchs, Chenglong Li, Veronica Olson, Tanios Bekaii-Saab, Jiayuh Lin,