| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8297955 | Biochemical and Biophysical Research Communications | 2011 | 7 Pages |
Abstract
⺠In this study, we explored the function of IGF-1Ea propeptide in inducing cardiogenesis of stem cells. ⺠IGF-1Ea promoted cardiac mesodermal induction in uncommitted cells. ⺠Under differentiation condition, IGF-1Ea increased expression of cardiac differentiation markers. ⺠Furthermore, it promoted formation of finely organized sarcomeric structure. ⺠IGF-1Ea propeptide may be a good candidate to improve production of cardiomyocytes from pluripotent cells.
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Authors
Bhawana Poudel, Daniel Bilbao, Padmini Sarathchandra, Renee Germack, Nadia Rosenthal, Maria Paola Santini,