| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8297956 | Biochemical and Biophysical Research Communications | 2011 | 7 Pages |
Abstract
⺠p300 acetylates conserved lysines within Notch1 C-terminal nuclear localization signal. ⺠MAML1 and CSL, components of Notch transcription complex, increase Notch acetylation. ⺠MAML1-dependent acetylation of Notch1 by p300 decreases the ubiquitination of Notch1. ⺠CDK8 inhibits Notch acetylation and Notch transcription enhanced by p300.
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Authors
Anita E. Popko-Scibor, Mikael J. Lindberg, Magnus L. Hansson, Teresa Holmlund, Annika E. Wallberg,