Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes

Article ID	Journal	Published Year	Pages	File Type
8297958	Biochemical and Biophysical Research Communications	2011	5 Pages	PDF

Abstract

âº Drug-induced toxicity is triggered by bile acids in SCHs. âº SCH-based model is useful for the evaluation of BA-dependent DILI. âº SCH-based model can reflect the effect of drug metabolism on BA-dependent DILI.

Keywords

IC50 NAPQI N-acetyl-p-benzoquinone imine BSEP/Bsep CYP450 1-aminobenzotriazole 50% inhibitory concentration Drug-induced liver injury Bile acid DILI Cytochrome P450 lactate dehydrogenase LDH inhibition constant Bile salt export pump