| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8297966 | Biochemical and Biophysical Research Communications | 2011 | 5 Pages |
Abstract
⺠ER stress induces expression of presenilin-1. ⺠Presenilin-1 induction is dependent on ATF4. ⺠ER stress upregulates γ-secretase activity and increases Aβ secretion. ⺠Quercetin suppresses ATF4 expression leading to decreased Aβ secretion.
Keywords
inositol-requiring protein-1GCN2CRTC2JnkATF4XBP-1HRIeIF2αPKRγ-SecretaseDAPTUPRIRE1c-Jun N-terminal kinaseN-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl esterPKR-like ER kinaseamyloid-βEndoplasmic reticulum stressAlzheimer’s diseaseDiabetesendoplasmic reticulumeukaryotic initiation factor 2αactivating transcription factor 4ObesityHeme-regulated inhibitorUnfolded protein responsePresenilinPERKgeneral control non-derepressible 2Quercetin
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Authors
Kazunori Ohta, Akihito Mizuno, Shimo Li, Masanori Itoh, Masashi Ueda, Eri Ohta, Yoko Hida, Miao-xing Wang, Manabu Furoi, Yukihiro Tsuzuki, Mitsuaki Sobajima, Yoshimasa Bohmoto, Tatsuya Fukushima, Masuko Kobori, Takashi Inuzuka, Toshiyuki Nakagawa,