Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8297967 | Biochemical and Biophysical Research Communications | 2011 | 5 Pages |
Abstract
⺠Cardiac myosin regulatory light chain (MYL2) is phosphorylated at S15. ⺠Smooth muscle myosin light chain kinase (smMLCK) is a ubiquitous kinase. ⺠It is a widely believed that MYL2 is a poor substrate for smMLCK. ⺠In fact, smMLCK efficiently and rapidly phosphorylates S15 in MYL2. ⺠Phosphorylation kinetics measured by novel fluorescence method without radioactivity.
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Authors
Matthew P. Josephson, Laura A. Sikkink, Alan R. Penheiter, Thomas P. Burghardt, Katalin Ajtai,