Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8297969 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠We demonstrated that HBV represses MIA2 gene expression both invitro and in vivo. ⺠The X protein of HBV plays a major role in such regulation. ⺠Knock-down of MIA2 in HepG2 cells activates cell growth and proliferation. ⺠HBx activates cell proliferation, over-expression of MIA2 impaired such regulation. ⺠HBx activates hepatoma cell proliferation through repressing MIA2 expression.
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Authors
Yilin Xu, Yang Yang, Yanyan Cai, Fang Liu, Yingle Liu, Ying Zhu, Jianguo Wu,