Article ID Journal Published Year Pages File Type
8297974 Biochemical and Biophysical Research Communications 2011 7 Pages PDF
Abstract
► We investigated whether ATP release was regulated during ischemia in cardiomyocytes. ► Ischemic stress rapidly increased the extracellular ATP. ► The ATP increase was reversed by treatment with blockers of maxi-anion channels. ► Maxi-anion channel blocking at later ischemia paradoxically increased ATP release. ► The increase was significantly suppressed by co-treatment with hemichannel blockers.
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Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Negative-feedback regulation of ATP release: ATP release from cardiomyocytes is strictly regulated during ischemia
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