Single-nucleotide polymorphisms (SNPs) of the IRF6 and TFAP2A in non-syndromic cleft lip with or without cleft palate (NSCLP) in a northern Chinese population

Article ID	Journal	Published Year	Pages	File Type
8298016	Biochemical and Biophysical Research Communications	2011	5 Pages	PDF

Abstract

âº IRF6 rs642961 polymorphism is intensively associated with NSCLP. âº IRF6 rs2235371 polymorphism is not associated with NSCLP in the northern Chinese population. âº This investigation failed to yield any evidence for the involvement of TFAP2A polymorphisms in NSCLP in the northern Chinese population.

Keywords

Tfap2a IRF6 LDR MAF CLO CLP HWE Hardy–Weinberg equilibrium Cleft lip and palate interferon regulatory factor 6 Linkage disequilibrium minor allele frequency Association study PCR polymerase chain reactions SNP Candidate gene