| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8298094 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠Hepatocellular carcinoma is inhibited by Spred2 through as yet unclear mechanisms. ⺠We studied the overexpression of Spred2 in cell line and murine tumor models of HCC. ⺠Spred2 inhibited cell proliferation and migration via attenuating ERK signaling. ⺠Spred2 overexpression induced apoptosis via caspase-3 and downregulated Mcl-1. ⺠A Spred2 knockdown markedly induced tumor growth in vivo.
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Authors
Xiao-Ni Ma, Xiao-Yun Liu, Yue-Feng Yang, Feng-Jun Xiao, Qing-Fang Li, Jun Yan, Qun-Wei Zhang, Li-Sheng Wang, Xue-Yan Li, Hua Wang,