| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8298134 | Biochemical and Biophysical Research Communications | 2011 | 7 Pages |
Abstract
⺠We found that a population of the human diploid fibroblasts can escape from Ras-induced senescence. ⺠Senescence-escaped cells lost p16 expression but did not exhibit the transforming potential. ⺠Disruption of p53 and Rb provided the transforming potential of senescence-escaped cells. ⺠Transformed senescence-escaped cells were highly aneuploid. ⺠Senescence-escaped cells were positive for Oct3/4, SOX2 and Nanog.
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Authors
Shinji Kohsaka, Ken Sasai, Kenta Takahashi, Tsuyoshi Akagi, Mishie Tanino, Taichi Kimura, Hiroshi Nishihara, Shinya Tanaka,