Article ID Journal Published Year Pages File Type
8298168 Biochemical and Biophysical Research Communications 2011 6 Pages PDF
Abstract
► NaF reduced the cell viability of MC3T3-E1 in a temporal and concentration dependent manner. ► NaF promoted apoptosis due to a decrease in the bcl-2/bax ratio at both the mRNA and protein levels. ► NaF treatment induced MC3T3-E1 S-phase arrest. ► Bcl-2 family proteins are involved in fluoride induced osteoblast apoptosis.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Sodium fluoride induces apoptosis and alters bcl-2 family protein expression in MC3T3-E1 osteoblastic cells
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