Involvement of NADPH oxidase 1 in UVB-induced cell signaling and cytotoxicity in human keratinocytes

Article ID	Journal	Published Year	Pages	File Type
8298384	Biochemistry and Biophysics Reports	2018	9 Pages	PDF

Abstract

Collectively, these data suggest that Nox1-mediated ROS production is required for UVB-induced cytotoxicity and inflammation through p38 activation and inflammatory cytokine production, such as IL-6. Thus, our findings suggest Nox1 as a therapeutic target for cytotoxicity and inflammation in response to UVB exposure.

Keywords

STAT3 Jun N-terminal kinases MKP O2-ASK1 GM-CSF ERK NAC UVB Jnk IL-6 DPI NF-κB PBS DNA H2DCFDA MAPK MAPK phosphatase MKK NADPH oxidase 1 NOx ROS Hydrogen peroxide deoxyribonucleic acid RNA ribonucleic acid Ultraviolet NADPH oxidase interleukin-6 Bax tumor necrosis factor-alpha Diphenyleneiodonium Hydroxyl radical Cytotoxicity Superoxide granulocyte-macrophage colony-stimulating factor TNF-α nuclear factor kappa B lactate dehydrogenase LDH signal transducer and activator of transcription 3 Phosphate-buffered saline N-acetyl cysteine H2O2 BCL2-associated X protein mitogen-activated protein kinase Keratinocyte MAP kinase extracellular signal-regulated kinase apoptosis signal-regulating kinase 1 Reactive oxygen species