| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8298461 | Biochemistry and Biophysics Reports | 2018 | 6 Pages |
Abstract
In this study, we investigated dominant functional themes and centrality parameters including betweenness as well as the degree of each topological clusters and expressionally active sub-networks in the resulted network. The results of functional analysis on gene sets showed that neurotrophin signaling pathway, cell cycle and nucleotide excision possess the strongest enrichment signals. According to the computed centrality parameters, HNF4A, TAF1 and TP53 manifested as the most significant nodes in the interaction network of the engaged proteins in gastric cancer. This study also demonstrates pathways and proteins that are applicable as diagnostic markers and therapeutic targets for future attempts to overcome gastric cancer.
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Authors
Mohammad Saberi Anvar, Zarrin Minuchehr, Mohsen Shahlaei, Samira Kheitan,