IAPP in type II diabetes: Basic research on structure, molecular interactions, and disease mechanisms suggests potential intervention strategies

Article ID	Journal	Published Year	Pages	File Type
8299294	Biochimica et Biophysica Acta (BBA) - Biomembranes	2018	53 Pages	PDF

Keywords

IAPP HSQC pKa EGCG CGRP AFM ERAD GLP-1 PKC hIAPP MCP1 SRE GAGs FOXA2 TXNIP Jnk TIRFM Forkhead box protein A2 total internal reflection fluorescence microscope Calcitonin gene-related peptides 2DIR Receptor activity modifying proteins NF-κB endoplasmic reticulum-associated protein degradation LUVs SDS ssNMR PTM Pdx1 nuclear magnetic resonance Janus kinase DMSO ERKs Pancreatic and duodenal homeobox 1 HSPGs Solid-state NMR Micro RNAs Amyloids Amylin Post translational modification insulin epigallocatechin gallate Tem large unilamellar vesicles ThT IDPs NMR Electron paramagnetic resonance EPR tumor necrosis factor-α Thioflavin T Serum amyloid P component Diabetes mellitus Type II diabetes mellitus Dimethyl sulfoxide ramp circular dichroism sodium dodecyl sulfate Age endoplasmic reticulum SAP Structure-based drug design FT-IR Fourier transform infrared spectroscopy heteronuclear single-quantum correlation spectroscopy Membrane TNF-α MiRNA Transmission electron microscopy atomic force microscopy Nanoparticle thioredoxin-interacting protein monocyte chemo-attractant protein-1 Intrinsically disordered proteins protein kinase A Protein kinase C heparan sulfate proteoglycans prohormone convertase human islet amyloid polypeptide glucagon-like peptide 1 H-bond Hydrogen bond Extracellular signal–regulated kinases Glycosaminoglycans

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IAPP in type II diabetes: Basic research on structure, molecular interactions, and disease mechanisms suggests potential intervention strategies

Authors

Shreyasi Asthana, Bibekanand Mallick, Andrei T. Alexandrescu, Suman Jha,