The major outer membrane protein of Legionella pneumophila Lpg1974 shows pore-forming characteristics similar to the human mitochondrial outer membrane pore, hVDAC1

The graphical abstract shows the prospective cross section of Lpg1974 seen perpendicular to the cell surface in two versions, one with the N-terminal extension (Lpg1974) and one without the leader sequence. The structure of the channel was adapted according to the structure of hVDAC1 (PBD ID: 2JK4.pdb). The right panel shows the voltage dependence of the two versions of Lpg1974, the one with (Lpg1974) and the one without the N-terminal extension (Lpg1974Δ1-21).149