| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8300010 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 7 Pages |
Abstract
⺠Membrane cholesterol stabilizes ligand binding of the serotonin1A receptor. ⺠This is analogous to the stabilizing role of trehalose for proteins. ⺠These results have implications in future crystallization efforts of the receptor.
Keywords
Dimyristoyl-sn-glycero-3-phosphocholine8-hydroxy-2(di-N-propylamino)tetralin5-hydroxytryptamine-1A receptorBCATRISdMPCDPHPMSF8-OH-DPATGPCRMβCDCAPSCRAC1,6-diphenyl-1,3,5-hexatriene3-[cyclohexylamino]-1-propanesulfonic acid5-HT1A receptorBSACCmG-protein coupled receptortris-(hydroxymethyl)aminomethanebovine serum albuminFluorescence anisotropybicinchoninic acidcholesterol recognition/interaction amino acid consensusThermal deactivationphenylmethylsulfonyl fluorideLigand bindingmethyl-β-cyclodextrincholesterolcholesterol consensus motif
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Authors
Roopali Saxena, Amitabha Chattopadhyay,