Membrane structure and interactions of peptide hormones with model lipid bilayers

► The behavior of the AVP and OT-like peptides at a level of peptide-lipid interactions. ► The hydrophobic modification improves the peptide insertion into the lipid bilayer. ► The hydrophobic interactions between the peptides and liposomes determine the overall conformation of the peptide. ► The electrostatic interactions become relevant for the AVP-like peptides above Tm.