| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8300112 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 9 Pages |
Abstract
⺠The hydrolysis of membrane phospholipids by RVV acidic PLA2 was studied. ⺠Catalytic and membrane damaging activities of RVVPLA2âI are correlated. ⺠The RVVPLA2âI preferentially hydrolyzed PC of mitochondrial membrane. ⺠GC analysis of fatty acids released from different membranes demonstrated distinct results. ⺠Differential membrane damage suggests the presence of PLA2-sensitive membrane domains.
Keywords
IAAN-α-p-tosyl-l-lysine chloromethyl ketoneDTTPbPbAcidic phospholipase A2RVVTPCKTLCKp-Bromophenacyl bromideMembrane damageFatty acidTosyl phenylalanyl chloromethyl ketoneRussell's viper venomdithiothreitolHT-29 cellphosphatidylcholinephosphatidylethanolaminePhosphatidylserineMitochondrionErythrocyteiodoacetamide
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Authors
Debashree Saikia, Naba K. Bordoloi, Pronobesh Chattopadhyay, S. Choklingam, Siddhartha S. Ghosh, Ashis K. Mukherjee,