| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8300170 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2011 | 9 Pages |
Abstract
⺠We present a simple and small molecule (BTA-EG4), which forms remarkably well-defined ion channels in lipid bilayers. ⺠This small molecule is composed of a benzothiazole aniline (BTA) group attached to tetra(ethylene glycol). ⺠These pores are formed by the self-assembly of approximately four monomers of BTA-EG4. ⺠The BTA-EG4 pores are selective for monovalent cations in the following sequence: H+ >> Cs+ > K+ > Na+ > Li+. ⺠BTA-EG4 exhibits antibiotic activity against gram-positive bacteria and cytotoxicity against human neuroblastoma cells.
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Authors
Panchika Prangkio, Divya K. Rao, Kevin D. Lance, Mark Rubinshtein, Jerry Yang, Michael Mayer,