| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8300201 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2011 | 8 Pages |
Abstract
⺠We review the domain organization of phospholipase Cb and relate this to modes of activation. ⺠We suggest how binding of PLCβ2 at the membrane surface through its PH domain induces activation. ⺠We discuss the role of the insertion loop as a model for activation. ⺠We present a comprehensive structure-based model of PLCβ2 activation states at the membrane. ⺠We discuss future challenges in the regulation of PLCβ enzymes in cellular settings.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Harel Weinstein, Suzanne Scarlata,