| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8300242 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2011 | 9 Pages |
Abstract
⺠Ribonucleases can be cytotoxic for tumor cells. ⺠Ribonuclease cytotoxicity depends on membrane interaction. ⺠The ribonuclease-membrane interaction is a two-step process. ⺠The G38K variant of bovine seminal-ribonuclease has a stronger membrane interaction. ⺠Membrane interaction capability of ribonucleases correlates with their cytotoxicity.
Keywords
dimyristoyl phosphatidylglycerolMLVsDMEMESRLUVsDMPGPBSdLPG3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideDulbecco's modified Eagle's mediumMTTSUVsmultilamellar vesicleslarge unilamellar vesiclesSurface plasmon resonanceSPRMembrane interactionEIEMelting TemperatureElectron spin resonancecircular dichroismPhosphate buffered salinesmall unilamellar vesicles
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Authors
Gerardino D'Errico, Carmine Ercole, Marisa Lista, Elio Pizzo, Annarita Falanga, Stefania Galdiero, Roberta Spadaccini, Delia Picone,