Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8300423 | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | 2018 | 17 Pages |
Abstract
Histone deacetylases deacetylate histone and non-histone protein targets. Aberrant HDAC expression and function have been observed in several diseases, which make these enzymes attractive treatment targets. Here, we summarize recent literature that addresses the roles of HDAC11 on the regulation of different immune cells including neutrophils, myeloid derived suppressor cells and T-cells. HDAC11 was initially identified as a negative regulator of the well-known anti-inflammatory cytokine IL-10. Hence, antagonizing HDAC11 activity may have anti-tumor potential, whereas activating HDAC11 may be useful to treat chronic inflammation or autoimmunity. However, to anticipate biological side-effects of HDAC11 modulators, more molecular insights will be required.
Keywords
APCTregSAHAPAMPHDACiMDSCCTCLPTCLHEK293miR145HDACHDAC11FDADAMPTCrGvHDSmall interfering RNAsiRNAU.S. Food and Drug AdministrationSuberoylanilide hydroxamic aciddamage associated molecular patternEpigeneticsinterferonIFNinterleukinImmune systemRegulatory T cellDendritic cellmyeloid derived suppressor cellhuman embryonic kidney cells 293antigen presenting cellPeripheral T-cell lymphomaCutaneous T-cell lymphomaUTR یا untranslated regions untranslated regionhistone deacetylase inhibitorGene ontologyHistone acetyltransferasehistone deacetylasepathogen associated molecular patternGraft versus host diseaseHATT cell receptor
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Authors
Cansu Yanginlar, Colin Logie,