Article ID Journal Published Year Pages File Type
8300511 Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 2013 9 Pages PDF
Abstract
► The eukaryotic exosome is a major ribonuclease for RNA decay and processing. ► The repertoire of catalytic subunits varies among Eukaryota. ► Some catalytic subunits are compartment-specific and give rise to exosome isoforms. ► Substrate threading modulates ribonuclease activities in the holocomplex. ► The many cellular functions of the exosome are mediated by auxiliary factors.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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