Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8300517 | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | 2013 | 10 Pages |
Abstract
⺠Decapping inactivates translation initiation and initiates 5â²-to-3â² decay of mRNA. ⺠The Dcp1-Dcp2 decapping complex is widely conserved among eukaryotes. ⺠An open-to-closed transition controls the activity of the Dcp1-Dcp2 complex. ⺠Multiple enhancers of decapping promote decapping by different mechanisms. ⺠mRNAs that accumulate with decapping complexes can assemble into P bodies.
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Authors
Marcos Arribas-Layton, Donghui Wu, Jens Lykke-Andersen, Haiwei Song,