Article ID Journal Published Year Pages File Type
8300526 Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 2013 12 Pages PDF
Abstract
► Translation termination distant from PABP triggers NMD. ► EJCs are enhancers of NMD and differentially deposited onto spliced mRNA. ► UPF1 ATPase and RNA helicase is tightly regulated ► Phosphorylation of UPF1 is crucial for NMD but appears to not affect UPF1 ATPase/helicase activities. ► SMG5, SMG6, SMG7 and PNRC2 appear to promote mRNA decay through different routes.
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Nonsense-mediated mRNA decay - Mechanisms of substrate mRNA recognition and degradation in mammalian cells
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