| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8300582 | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | 2012 | 10 Pages |
Abstract
⺠let-7 miRNA directly binds to the 3'-UTR of Bach1 and negatively regulates Bach1 gene expression. ⺠let-7 miRNA thereby up-regulates the HMOX1 gene expression. ⺠Over-expression of let-7 miRNA attenuates oxidative injury in human hepatocytes.
Keywords
NQO1PAGEBCAqRT-PCRbZIPHMOX1GAPDHBACH1PVDFMINCFBSSDSDMEMtBuOOHMaf recognition elementDulbecco's modified Eagle MediumNAD(P)H:quinone oxidoreductaseROSLet-7polyacrylamide gel electrophoresisHITSbicinchoninic acidOxidative stressHigh-throughput sequencingbasic leucine zippersodium dodecyl sulfatefetal bovine serummareUTR یا untranslated regions untranslated regioncarbon monoxideMicroRNAMiRNAnucleotide(s)tert-butyl hydroperoxidequantitative reverse transcription-polymerase chain reactionWestern blotPolyvinylidene fluorideClipglyceraldehyde-3-phosphate dehydrogenaseReactive oxygen species
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Authors
Weihong Hou, Qing Tian, Nury M. Steuerwald, Laura W. Schrum, Herbert L. Bonkovsky,