Article ID Journal Published Year Pages File Type
8300603 Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 2012 9 Pages PDF
Abstract
► Myogenin was identified as a novel αNAC target gene. ► αNAC interacts with the corepressors HDAC1 and HDAC3. ► αNAC recruits HDAC1/3 to the promoter of silent, but not expressed, target genes. ► A mutant αNAC not interacting with HDACs cannot inhibit Myogenin or myogenesis. ► We propose new roles for αNAC in transcriptional control during differentiation.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
αNAC interacts with histone deacetylase corepressors to control Myogenin and Osteocalcin gene expression
Authors
, , ,