Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8300603 | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | 2012 | 9 Pages |
Abstract
⺠Myogenin was identified as a novel αNAC target gene. ⺠αNAC interacts with the corepressors HDAC1 and HDAC3. ⺠αNAC recruits HDAC1/3 to the promoter of silent, but not expressed, target genes. ⺠A mutant αNAC not interacting with HDACs cannot inhibit Myogenin or myogenesis. ⺠We propose new roles for αNAC in transcriptional control during differentiation.
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Authors
Toghrul Jafarov, James W.M. Alexander, René St-Arnaud,