Article ID Journal Published Year Pages File Type
8300612 Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 2012 9 Pages PDF
Abstract
► We review TFAM-DNA interactions, including specificity, affinity, bending, and cooperativity. ► We review proposed mechanisms of TFAM regulation of mtDNA copy number. ► We propose a model in which TFAM dimerization, DNA looping, and cooperativity impact mtDNA packaging and promoter activity.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Mitochondrial transcription factor A regulates mitochondrial transcription initiation, DNA packaging, and genome copy number
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